NOT KNOWN DETAILS ABOUT PKRRATING

The activated enzyme then phosphorylates its significant substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved family members of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to unique stimuli12, triggering the bui